evaluation of cardioprotective effect of aqueous extract of garcinia indica linn. fruit rinds on isoprenaline-induced myocardial injury in wistar albino rats
نویسندگان
چکیده
in the present study,cardioprotective effect of aqueous extract of garcinia indica linn. fruit rinds in isoprenaline-induced myocardial infarction in wistar albino rats was evaluated. in vitro total phenolic, total flavonoid content and 2, 2’-diphenyl-1-picrylhydrazyl hydrate radical scavenging activity was measured. in vivo effect of aqueous extract of g. indica was evaluated in wistar albino rats by isoprenaline-induced myocardial injury model. thirty six rats were randomly divided in 6 groups. rats were treated with g. indica 250 mg/kg and 500 mg/kg doses for 21 days and myocardial injury was produced by subcutaneous injection of isoprenaline 85 mg/kg on day 20 and 21. carvedilol 1 mg/kg for 21 days served as active control. electrocardiogram parameters, cardiac injury markers (serum troponin-i, uric acid, lactate dehydrogenase, creatinine kinase-mb, aspartate aminotransferase and alanine aminotransferase), oxidative stress markers (superoxide dismutase, catalase and malondialdehyde level) and histopathological changes were evaluated in each group and compared using appropriate statistical tests. in vitro evaluation of aqueous extract showed significant antioxidant property. isoprenaline produced significant myocardial ischemia as compared to normal control group ( p <0.05). administration of g. indica in both the doses did not significantly recover the altered electrocardiogram, cardiac injury markers, oxidative stress markers and histopathological myocardial damage as compared to disease control group ( p >0.05). the aqueous extract of g. indica was not found to be cardioprotective against myocardial injury. further study with more sample size and higher dose range may be required to evaluate its cardioprotective effect.
منابع مشابه
Evaluation of cardioprotective effect of aqueous extract of Garcinia indica Linn. fruit rinds on isoprenaline-induced myocardial injury in Wistar albino rats
In the present study, cardioprotective effect of aqueous extract of Garcinia indica Linn. fruit rinds in isoprenaline-induced myocardial infarction in Wistar albino rats was evaluated. In vitro total phenolic, total flavonoid content and 2, 2'-diphenyl-1-picrylhydrazyl hydrate radical scavenging activity was measured. In vivo effect of aqueous extract of G. indica was evaluated in Wistar albino...
متن کاملthe effect of aqueous extract of garlic on formalin-induced pain in male rats
چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...
15 صفحه اولevaluation of cardioprotective effect of aqueous extract of allium cepa linn. bulb on isoprenaline-induced myocardial injury in wistar albino rats
to investigate the cardioprotective potential of the aqueous extract of allium cepa linn. bulb in isoprenaline-induced myocardial injury in wistar albino rats. in vitro total phenolic, total flavonoid content and 2, 2’-diphenyl-1-picrylhydrazyl hydrate radical scavenging activity was measured. isoprenaline-induced myocardial injury model was used to evaluate in vivo effect of aqueous extract of...
متن کاملEvaluation of cardioprotective effect of aqueous extract of Allium cepa Linn. bulb on isoprenaline-induced myocardial injury in Wistar albino rats
To investigate the cardioprotective potential of the aqueous extract of Allium cepa Linn. bulb in isoprenaline-induced myocardial injury in Wistar albino rats. In vitro total phenolic, total flavonoid content and 2, 2'-diphenyl-1-picrylhydrazyl hydrate radical scavenging activity was measured. Isoprenaline-induced myocardial injury model was used to evaluate in vivo effect of aqueous extract of...
متن کاملEvaluation of cardioprotective effect of silk cocoon (Abresham) on isoprenaline-induced myocardial infarction in rats
Objective: The study was conducted to evaluate cardioprotective effect of silk cocoon (Abresham) Bombyx mori (B. mori) on isoprenaline-induced myocardial infarction. This study deals with the cocoons, which is called Abresham in the Unani system of medicine. It is one of the 64 drugs which Avicenna has mentioned in Avicenna’s tract on cardiac drugs and used in the treatment of cardiovascular di...
متن کاملEvaluation of Cardioprotective Activity of Aqueous Extract of Garcinia Indica Linn
Objective: The aim was to evaluate cardioprotective activity of aqueous extract of Garcinia indica Linn fruit rinds. Methods: Wistar rats were divided into different groups. Two doses 250 mg/kg and 500 mg/kg b.w, p.o of the G. indica fruit rind extract (GIFE) were subjected for the evaluation of cardioprotective activity against isoproterenol (ISO) and ischemia reperfusion injury (IRI) induced ...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
research in pharmaceutical sciencesجلد ۱۰، شماره ۵، صفحات ۳۸۸-۰
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023